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bioW [2017-8-11 16:0:3]
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bioW [2017-8-11 16:0:3]

pimeloyl-CoA synthase (6-carboxyhexanoate-CoA ligase)
locus
BSU30240
pI
5.55
mw
29.48 kDa
protein length
259 aa Sequence Blast
gene length
777 bp Sequence Blast
function
biosynthesis of biotin
product
pimeloyl-CoA synthase
essential
no
ec
6.2.1.14
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.1|Biosynthesis/ acquisition of biotin]

    • Gene

    Coordinates
    3,094,679 → 3,095,455

    Phenotypes of a mutant

  • requires biotin for growth [Pubmed|28196402]

    • The protein

    Catalyzed reaction/ biological activity

  • ATP 6-carboxyhexanoate CoA = AMP diphosphate 6-carboxyhexanoyl-CoA (according to Swiss-Prot)

    • Protein family

  • bioW family (according to Swiss-Prot)

    • Structure

  • [PDB|5FLG] [pubmed|28414710]

    • Expression and Regulation

    Operons

    genes
    [gene|C40116089BAD3F9831F8C837DC4F2E045753ABDE|bioW]-[gene|68C86FED3575B864C576DFB73FE7B5BF83994D1F|bioA]-[gene|8B6A3E86A88928526D94FDA94B9C81ABF6E9ACFB|bioF]-[gene|D9A71DAF949FB6C9C22C8361D83C5A0741184977|bioD]-[gene|5880617EB95FC0D19219A868D6D0A3D1D0D9C532|bioB]-[gene|8FBC9A1AC108DC99E275D7A27C18C797D3CDB936|bioI]-[gene|089A32D08B5A7E552CBD9CB9745BD542863B4558|ytbQ]
    description
    [Pubmed|8763940,8892842]

    regulatory mechanism

  • [protein|F761DBCE3429C99159F8F7CD8596FD9CF2D0589D|BirA]: repression, [Pubmed|8763940,8892842], in [regulon|F761DBCE3429C99159F8F7CD8596FD9CF2D0589D|BirA regulon]

    • regulation

  • repressed in the presence of biotin ([protein|search|BirA]) [Pubmed|8763940,8892842]
    • view in new tab

    References

    Reviews

  • 21437340

    • Original publications

  • 8763940,8892842,11717296,12368242,28196402,28414710